Fri Sep 02 2022

46 articles - From Friday Aug 26 2022 to Friday Sep 02 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Ann Intern Med

Good Publication Practice (GPP) Guidelines for Company-Sponsored Biomedical Research: 2022 Update.

Incorporating the principles and best practices presented in these GPP guidelines will result in increased transparency and a firm ethical footing. This guidance is also intended to enable the compliant incorporation of new and emerging publication tools for the ethical publication of company-sponsored research.

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Meta-analysis

meta-analyses and systematic reviews

Lancet

SGLT-2 inhibitors in patients with heart failure: a comprehensive meta-analysis of five randomised controlled trials.

Interpretation SGLT2 inhibitors reduced the risk of cardiovascular death and hospitalisations for heart failure in a broad range of patients with heart failure, supporting their role as a foundational therapy for heart failure, irrespective of ejection fraction or care setting. Funding None.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

From Individualized Interactions to Standardized Schedules: A History of Time Organization in U.S. Outpatient Medicine.

Whereas early appointment systems depended on personal connection between schedulers and the physicians and patients they supported, today's schedulers have few such interactions. The widespread shift to centralized scheduling and standardized time slots has contributed to misalignment among time allocation, patient care, and health care workforce well-being and is likely exacerbating ongoing tensions among patients, physicians, and administrators.

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Tea Consumption and All-Cause and Cause-Specific Mortality in the UK Biobank : A Prospective Cohort Study.

Higher tea intake was associated with lower mortality risk among those drinking 2 or more cups per day, regardless of genetic variation in caffeine metabolism. These findings suggest that tea, even at higher levels of intake, can be part of a healthy diet. Primary funding source National Cancer Institute Intramural Research Program.

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The Association of Baseline Plasma SARS-CoV-2 Nucleocapsid Antigen Level and Outcomes in Patients Hospitalized With COVID-19.

Elevated plasma antigen is highly associated with both severity of pulmonary illness and clinically important patient outcomes. Multiple clinical and viral factors are associated with plasma antigen level at presentation. These data support a potential role of ongoing viral replication in the pathogenesis of SARS-CoV-2 in hospitalized patients. Primary funding source U.S. government Operation Warp Speed and National Institute of Allergy and Infectious Diseases.

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Lancet

A telemedicine model for abortion in South Africa: a randomised, controlled, non-inferiority trial.

Interpretation Asynchronous online consultation and instruction for medical abortion and home self-medication, with uterine palpation as the only in-person component, was non-inferior to standard care with respect to rates of complete abortion, and did not affect safety, adherence, or satisfaction. Funding Grand Challenges Canada and the Swedish Research Council.

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Autoimmune diseases and cardiovascular risk: a population-based study on 19 autoimmune diseases and 12 cardiovascular diseases in 22 million individuals in the UK.

Interpretation These findings warrant targeted cardiovascular prevention measures, in particular in younger patients with autoimmune diseases, and further research into pathophysiological mechanisms underlying these complications. Funding Horizon 2020 Marie Sklodowska-Curie Actions and European Society of Cardiology.

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Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial.

Combination treatment was well tolerated and led to improved pain relief in patients with suboptimal pain control with a monotherapy. Funding National Institute for Health Research (NIHR) Health Technology Assessment programme.

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N Engl J Med

Acetazolamide in Acute Decompensated Heart Failure with Volume Overload.

The addition of acetazolamide to loop diuretic therapy in patients with acute decompensated heart failure resulted in a greater incidence of successful decongestion. (Funded by the Belgian Health Care Knowledge Center; ADVOR ClinicalTrials.gov number, NCT03505788.).

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Blood-Pressure Targets in Comatose Survivors of Cardiac Arrest.

Targeting a mean arterial blood pressure of 77 mm Hg or 63 mm Hg in patients who had been resuscitated from cardiac arrest did not result in significantly different percentages of patients dying or having severe disability or coma. (Funded by the Novo Nordisk Foundation; BOX ClinicalTrials.gov number, NCT03141099.).

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Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.

Dapagliflozin reduced the combined risk of worsening heart failure or cardiovascular death among patients with heart failure and a mildly reduced or preserved ejection fraction. (Funded by AstraZeneca; DELIVER ClinicalTrials.gov number, NCT03619213.).

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Efficacy and Safety of an Extravascular Implantable Cardioverter-Defibrillator.

In this prospective global study, we found that extravascular ICDs were implanted safely and were able to detect and terminate induced ventricular arrhythmias at the time of implantation. (Funded by Medtronic; ClinicalTrials.gov number, NCT04060680.).

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Five-Year Outcomes of the Danish Cardiovascular Screening (DANCAVAS) Trial.

After more than 5 years, the invitation to undergo comprehensive cardiovascular screening did not significantly reduce the incidence of death from any cause among men 65 to 74 years of age. (Funded by the Southern Region of Denmark and others; DANCAVAS ISRCTN Registry number, ISRCTN12157806.).

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Oxygen Targets in Comatose Survivors of Cardiac Arrest.

Targeting of a restrictive or liberal oxygenation strategy in comatose patients after resuscitation for cardiac arrest resulted in a similar incidence of death or severe disability or coma. (Funded by the Novo Nordisk Foundation; BOX ClinicalTrials.gov number, NCT03141099.).

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Percutaneous Revascularization for Ischemic Left Ventricular Dysfunction.

Among patients with severe ischemic left ventricular systolic dysfunction who received optimal medical therapy, revascularization by PCI did not result in a lower incidence of death from any cause or hospitalization for heart failure. (Funded by the National Institute for Health and Care Research Health Technology Assessment Program; REVIVED-BCIS2 ClinicalTrials.gov number, NCT01920048.).

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Polypill Strategy in Secondary Cardiovascular Prevention.

Treatment with a polypill containing aspirin, ramipril, and atorvastatin within 6 months after myocardial infarction resulted in a significantly lower risk of major adverse cardiovascular events than usual care. (Funded by the European Union Horizon 2020; SECURE ClinicalTrials.gov number, NCT02596126; EudraCT number, 2015-002868-17.).

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Rivaroxaban in Rheumatic Heart Disease-Associated Atrial Fibrillation.

Among patients with rheumatic heart disease-associated atrial fibrillation, vitamin K antagonist therapy led to a lower rate of a composite of cardiovascular events or death than rivaroxaban therapy, without a higher rate of bleeding. (Funded by Bayer; INVICTUS ClinicalTrials.gov number, NCT02832544.).

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Routine Functional Testing or Standard Care in High-Risk Patients after PCI.

Among high-risk patients who had undergone PCI, a follow-up strategy of routine functional testing, as compared with standard care alone, did not improve clinical outcomes at 2 years. (Funded by the CardioVascular Research Foundation and Daewoong Pharmaceutical; POST-PCI ClinicalTrials.gov number, NCT03217877.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Rugers, Remingtons, and Reality: A Gun Lover's Plea for a Safer Second Amendment.

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Lancet

Tedros: Tigray, the Triple Billion, and a second term.

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N Engl J Med

Anticoagulation in Atrial Fibrillation and Rheumatic Heart Disease.

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Covid-19 Vaccines - Immunity, Variants, Boosters.

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DELIVERing Progress in Heart Failure with Preserved Ejection Fraction.

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New Decongestion Strategies in an Evolving Heart Failure Landscape.

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REVIVE-ing a Weak Heart - Details Matter.

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Surveillance Stress Testing "POST-PCI" - A Future Class III Recommendation?

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The Polypill at 20 - What Have We Learned?

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

Summary for Patients: Black Tea Consumption and Risk for Death.

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Lancet

"Every challenge is here": fistula in Ethiopia.

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A 1000-year-old case of Klinefelter's syndrome diagnosed by integrating morphology, osteology, and genetics.

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A new Lancet Commission on the future of health and economic resiliency in Africa.

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Autoimmune diseases and atherothrombotic risk.

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Effective treatment pathways exist for DPNP.

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Randomised trials of medical abortion provide some but not all the answers.

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SGLT2 inhibitors as the bedrock of therapy for heart failure.

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The Rohingya genocide and lessons learned from Myanmar's Spring Revolution.

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Ukraine invasion: 6 months on.

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N Engl J Med

"Fertility Fraud" Legislation - A Turning Point for Informed Consent?

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Intradermal Vaccination for Monkeypox - Benefits for Individual and Public Health.

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Losing Contact - Covid-19, Telemedicine, and the Patient-Provider Relationship.

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Responding to the Escalating Cybersecurity Threat to Health Care.

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Severe Subcutaneous Emphysema.

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Updated Health Warnings for Alcohol - Informing Consumers and Reducing Harm.

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What Dobbs Means for Patients with Breast Cancer.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Trust made the difference for democracies in COVID-19.

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N Engl J Med

Risk of BA.5 Infection among Persons Exposed to Previous SARS-CoV-2 Variants.

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